Ambulatory care use among patients with spina bifida: Change in care from childhood to adulthood. Shepard CL, Doerge EJ, et al. J Urol April 2018 - review by H Goldman
For the first time ever, there are now more adults with spina bifida (SB) than children as 85% of those with SB live well into adulthood.These patients have complex health needs that can evolve as they get older.
Videourodynamic analysis of the urethral sphincter overactivityand the poor relaxing pelvic floor muscles in women with voiding dysfunction. Peng CF, Chen SF, Kuo HC. Neurourol Urodyn. Nov 2017
In this study, the authors use videourodynamic studies to characterise voiding functions in a large cohort of women with voiding dysfunction and conclude that women with dysfunctional voiding (DV) had VUDS characteristics of bladder outlet obstruction (BOO) and urodynamic DO. Though the clinical symptoms of women with poor relaxation of the external sphincter (PRES) were similar to those of DV, patients had low detrusor contractility and low DO rates.
Improvement in LUTS across multiple domains following ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus. Krzastek,SC, Robinson SP, et al. Neurourol Urodyn. Nov 2017 - review by J Panicker
This study in patients with idiopathic normal pressure hydrocephalus (NPH) has shown that after surgical treatment of NPH by ventriculoperitoneal shunting, urinary symptoms improve significantly, specifically in terms of urinary urgency and urge incontinence as well as overall quality of life.
Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical study. Coelho A, Antunes-Lopes T, et al. Neurourol Urodyn. Nov 2017 - review by J Panicker
This study in human bladders from cadaveric organ donors demonstrates the presence of the Beta-3 adrenoceptor in acetylcholine-containing nerve fibers in the suburothelium. The study adds another perspective to how Beta-3 adrenoceptor agonists work in OAB.
Bladder Reconstruction Rates Differ among Centers Participating in National Spina Bifida Patient Registry. Routh JC, Joseph DB, Liu T, et al. J Urol: Jan 2018 - review by HB Goldman
Spina bifida (SB) is the most common disabling birth defect in the US and neurogenic bladder dysfunction is the norm in these patients. The National Spina Bifida Patient Registry (NSBPR) was established to document care patterns and ultimately improve the care of these patients
Is Detrusor Contraction during Rapid Bladder Filling Caused by Cold or Warm Water? A Randomized, Controlled, Double-Blind Trial. Kozomara M, Mehnert U, Seifert B, Kessler TM. J Urol: Jan 2018 - review by HB Goldman
The ice water test is thought to cause C-fiber mediated responses of the bladder particularly in neurogenic patients.
Home Urodynamic Pressures and Volume Measurement for the Neurogenic Bladder; Hidas G, Soltani T, Billimek J, et al, J Urol: Dec 2017- review by HB Goldman
This study describes an easy, inexpensive method of monitoring bladder pressures in between their routine visits to their urologists in children with spina bifida who have been optimized with anticholinergics and are dependent on CIC
Triggered Urine Interleukin-6 Correlates to Severity of Symptoms in Nonfebrile UTI's. Sunden F, Butler D, Wullt B. Urol. July 2017 - review by HB Goldman
Sunden et al from Lund, Sweden describe the use of
Interleukin-6 to distinguish severity of UTIs and potentially discriminate
between asymptomatic bacteriuria (ASB) and UTI in patients with elevated
residual urine and neurogenic bladder.
Long-Term Efficacy and Safety of OnabotulinumtoxinA in Patients with NDO - Rovner E, Kohan A, Chartier-Kastler E, et al. J Urol: Sept 2016 - Review by HB Goldman
NDO patients who had completed and initial 1 year Onabotulinum toxin A study were allowed to continue in a 4 year extension study.
AUS in male patients with spina bifida - Khene ZE, Paret F, Perrouin- Verbe MA,et al. J Urol: Sept 2017 - Review By HB Goldman
A retrospective analysis of the French spina bifida network database was performed to evaluate outcome differences between those patients who had an artificial urinary sphincter implanted with the cuff at the bulbar urethra versus those with the cuff at the bladder neck.